To refine the general profile theme of ‘Science for Sustainability’, a number of focused ‘research clusters’ have been developed via a bottom-up process involving both junior and senior researchers. The ASI clusters address some of today’s most urgent challenges and are linked to one or more Sustainable Development Goals (SDGs). Their membership consists of researchers with various disciplinary backgrounds, engaging in a broad spectrum of activities, often together with societal actors. The aim of the clusters is to stimulate ASI researchers to work together in order to generate innovative interdisciplinary research and create maximum sustainability impact. Clusters report about their activities to the ASI scientific steering committee. Each cluster has at least two coordinators from different faculties.